Reproduction problems Essay Example | Topics and Well Written Essays - 1000 words

Reproduction problems - Essay Example In the case of this patient the deficiency of 21 Hydroxylase led to the over production of androgen in the adrenal gland, which caused virilence in the patient. The exact pathophysiology of this disease will be explained in detail in the following section. 21Hydroxylase is specifically located in the endoplasmic reticulum of the zona fasciculate of the adrenal gland. It main function is the catalysis of 17 hydroxyprogesterone to a compound known as 11 deoxycortisol utilizing the glucocorticoid mechanism (Nieschlang et al., 42-55).The pathway begins with pregnenolone and ends with cortisol. It also acts as a catalyst in the pathway of progesterone to 11 deoxycortisteronne. Therefore, the deficiency of this enzyme affects both the glucocorticoid and mineralocorticoid pathways. The alsom leads to the hyperplasia of the adrenal cortex and elevates the level of ACTH (Nieschlang et al., 42-55). Since the catalytic step of the reactions is inhibited, there is an accumulation of 17 hydroxypr egnenolone and progesterone in the adrenal cortex. The level of 17 hydroxypregnenolone is elevated by approximately 500 times. 17 hydroxypregnenolone is utilized in the synthesis of androstenedione, DHEA and testosterone therefore excessive accumulation of this steroid hormone has led to the ambiguous external genitalia. The ovaries inside the patient are normal and the fallopian tubes, uterus and upper vagina are also normal due to the fact that they are not exposed to testicular antimullerian hormone. The elevated levels of testosterone lead to the enlargement of phallus. The patient has stage 1 virilization due to the significantly enlarged clitoris (Nieschlang et al., 42-55). The therapeutic approach towards congenital 21 hydroxylase deficiency is complicated and requires long term care and management. The patient should be admitted to the pediatric endocrine clinic. The management approaches require the following issues to be addressed and these include stress coverage, parenta l education and crisis prevention, monitoring and initiating hormonal replacement, optimizing the growth of the patient, reconstructive surgery of the external genetalia and optimizing the suppression of androgens and the future fertility of these infants. The hormonal replacement in newborns with CAH is to protect them from developing insufficiency of the adrenal gland and to also stomp the enhanced production of androgens. The hormonal replacement involves the administration of glucocorticoids which act as a substitute of cortisol thereby reducing the excessive amount of ACTH production. The parents of the child should also be educated on the nature of treatment as the administration of glucocorticoids is independent of the health condition of the patient and stopping administration may lead to death by adrenal crisis. The doses should never be missed. Case 2 The patient had 5 alpha reductase deficiency which is an autosomal recessive intersex disorder which occurs as a result of genetic mutation. This leads to the deficiency in the 5 alpha reductase type II gene (Costanzo, 10-20).The reactions that are catalyzed by 5 alpha reductase deficiency lead to the production of testosterone, therefore this process is inhibited. This enzyme is also responsible for the conversion of testosterone to DHT. The enzyme is expressed in the external genitalia in the early gestational period and is an important influence on the physiological development of male external

Waiting for a Delayed Flight Essay Example | Topics and Well Written Essays - 750 words

Waiting for a Delayed Flight - Essay Example The implications of such a delay are equally very costly, not only to an individual traveler but also to the flight company as well (Forbes, 2). Flight delays result from such reasons as repair and maintenance of the aircraft, security issues domestically or within the intended destination, issues stemming from the airport crew as well as possible delays in the arrival of the respective aircraft. Other causes may be such as delays in baggage loading, furling, traffic congestion and such natural calamities as unfavorable weather conditions. In the event that such unfortunate occurrences happen, passengers awaiting departure often suffer greatly. The result of delayed flight includes lateness for strategic appointments, failure to meet deadlines as well as losses from delayed delivery of perishable products among others. Besides such losses, individuals often are stranded within the airport and are likely to incur other costs such as in refreshments as well as securing personal accommo dation services in case the delay is beyond a single day. I happened to experience a flight delay in a leading African tourism destination where I spent my summer holiday last year. This formed a memorable experience in my life has never experienced such in my years of air travel. Though accompanied by my parents, I felt so much devastated by the experience because this was the first time I experienced such a delay. The airport had very disturbing loud noises from the landing and taking off air engines, which made me have a very severe headache. My parents decided to take a stroll in the neighborhood of the airport but I was unable to accompany them due to a headache I suffered. They took me to one of the waiting bays where barely anyone else was and left me lodged on a chair as is shown by the picture. This was equally no comfortable as the disturbing noises were still very loud and clear. Moreover, the sight of the landing and taking off planes kept disturbing me as the waiting ba y provided a very clear view of the running lanes.

Black Nationalism Essay Example | Topics and Well Written Essays - 1250 words

Black Nationalism - Essay Example ings in a comprehensive manner; comparing various views, common sense, philosophical tendencies, and/ or set of ideas that are proposed by class that is dominant in a given society (Michael 6). The main logic behind ideology is to bring about change that is deemed desirable in the society, or through a normative process, facilitate adherence to certain ideals where there is already the existence of conformity. The use of ideology in search for freedom among the blacks is one of the most evident across the world. This is because, for a long time the blacks have been advocating for gaining the national identity like the other races. Their advocacy was informed by the fact that the blacks across the world were under various forms of bondage namely colonialism in Africa and slavery in America. As a result, they were racially discriminated, and politically and economically sidelined in addition to losing their identity, thus, the rise of Black Nationalism. In the United States, Black Nationalism referred to a social and political movement that held set of beliefs that the American Americans should have political, economic, and social institutions that are distinct and separate from those of white society. This discussion will critically analyze the significance of black separatism ideological approach that was beneficial to the Black quest for freedom and self- determination. The ideology of Black separatism was one of the major ideologies under the political slogan ‘Black Power’. The ideology was pushed forward by Black Power adherents who believed in Black autonomy and the need of blacks separating from the whites economically, politically, and socially. The ideology was prominent in the 1960s and 1970s during the Black Power movement that emphasized on recognition and respect of black race identity and advocated for the creation of black social and political institutions in order to promote the collective interests of the blacks and advance their values as well

Project Planning in Teams Essay Example | Topics and Well Written Essays - 1750 words

Project Planning in Teams - Essay Example This also allows the formation of work breakdown structure and defining the dependencies and relationships. Using the same, network activity diagram can be formulated which assists in identification of critical activities and paths and time for completion of projects i.e. minimum and maximum. (Thayer, 2000). Following up with the same, the essential cost and time factors can be allocated to each activity allowing the final estimate to be calculated for the project on the whole. Once the plan is in its final shape, it is referred to as the baseline of the project that eventually serves as a benchmark for comparison of each activity's completion. Such comparison lead to creation of experience and knowledge which betters the future planning by individuals involved in the process (Fleming, 2005). A specification document is mainly a written foundation that specifies the major set of requirements of a project. These set of specifications are generally vague in nature. Later an agreement is reached between the customer and the vendor that is a refined form of specifications document and has a legal value and it contains in finalized format what actually a customer needs (Pinto, Jun 2006). Structuring a project is rather an essentiality to proceed with the work. Based on the set of requirements agreed upon by the customer, the project manager formulates a structure according to which resources are allocated (Pinto, Jun 2006). Work Breakdown Structure Work Breakdown Structure or WBS is an important tool in structuring a project that mainly requires breaking a requirement in small bits and pieces that would be later compiled to form the whole of a project. WBS is extremely useful because it defines precisely the requirements of each bit of a project, and secondly, it also assists in formulation of milestones in the project, alongside the ease of having parallel running activities (Pinto, Jun 2006). Task Allocation One the WBS is formed; tasks are allocated to individuals and in

Sustainable Design Essay Example | Topics and Well Written Essays - 2250 words

Sustainable Design - Essay Example It is first remarkable that, as Yeang, p. 413, 2007, puts it concisely - "Nature regards humans as one of its many species. What differentiates humans is their capability to inflict devastating changes on the environment".3 One of the major human activities that hugely and adversely affect the environment is the burning of fossil fuels to produce energy for other down line human activities. It is now notable that fossil fuels, even in the first parts of the 21st century, still remain the major energy source. Thus, it stands to good reason that any project that can run on low energy consumption is a profitable one. This is in two senses - firstly, with low consumption of fossil fuels low emission of harmful gases is possible and, secondly, the low consumption of fossil fuels enables energy planners to buy more time to develop alternate sources for future consumption when it is believed that all fossil fuels on Earth will be completely exhausted. This paper, thus, is concerned entirely with one such human project - human architectural activity - that is being designed to consume low energy and produce low emissions. This is what is currently being defined as sustainable architecture. The first part the paper discusses sustainability, its definition and global perceptions and the second part is a critical review about a sustainable development in London, called BedZED, as a successful example, its analysis and evaluation of its various environmentally friendly features. Ecodesign: Yeang4 defines ecodesign, which may be taken as sustainable design in this case, as a built environment that is fully integrated within its natural environment. It is taken here that the concerned 'built environment' is the sustainable architecture that this paper is in search of. Yeang (2007), furthermore, severely cautions against misconceptions that technology alone can provide sustainable architecture. He states that simply putting a set of technologies commonly acknowledged as green such as solar arrays, photovoltaic, biological recycling systems, building automation systems and double-skin facades into a building can merit the term ecodesign. Also, if a high mark in a green-rating system can hardly be construed as satisfactory reason to call the built environment sustainable architecture(Yeang, 2007). Instead, Yeang (2007) implies that ecodesign, or sustainable architecture, can only be operational when the entire building interacts with its natural environment in such a manne r that all its inputs and outputs sustain the ecosystem within which it is built without upsetting its delicate balance of secure survival. In this sense Yeang (2007) believes that not only the building but all its associated activities, such as transportation, for example, must be integrated into its ecosystem where he implies

The informative speech. (Preparation Outline) Essay

The informative speech. (Preparation Outline) - Essay Example Have you ever know what are the psychological theories of aging process? II. I will inform you about the three major theories of aging process, their consequences on human mind. I have seen aged people around me with some problems. Some of them are expressive while some of them prefer to remain silent. III. I will inform you the different theories involved in aging process. There are biological as well as psychological theories. Basically I want to focus on the psychological theories of aging process. 2. Historically, the psychological study of human aging evolved in the twentieth century. Publications that mark this evolution are, for instance, Eisdorfer and Lawton (1973) and the first handbook on the psychology of aging edited by Birren and Schaie. 3.1. The Activity Theory: This theory is also known as implicit theory of aging or normal theory of aging. The theory was developed by Robert J. Havighurst in 1961. According to this theory, a successful aging takes place when older people remain active and maintain their social interactions. 3.2. Disangagement Theory: It is based on the observation in the USA study of Cumming and Henry (1979) According to this theory, â€Å"aging is an inevitable mutual withdrawal or disengagement, resulting in decreased interaction between aging person and others in the social systems he belongs to.† ii. Social activeness by encouraging them to stay in the company of same member group in our housing society such as senior citizens club. Taking proper and healthy diet and involve in some physical activities that will suit them. Aging is an inevitable process in everyones life. The information I provide you about aging will be useful to know scientifically and cognitively about aging process. I explain the major theories in which you can study human behaviour in aging period. Now be familiar with the aging

Business law ( a righteous strike ) case study based in oman

Business law ( a righteous strike ) based in oman - Case Study Example According to article 107, the management of a retail outlet has a chance to use the procedures that were approved by competent directorate to negotiate with their workers. The management can engage in a constructive dialog with the retail workers union officials to iron out the issues that are causing labor disputes. The process will involve a comprehensive dialogue where the workers can present their grievances and demands to the managers of the retail outlet for consideration. On the other hand, the company officials can present the facts on the table and explain the company’s ability to comply with the workers demands. Article 107 also outlines the procedure to be followed in resolving such disputes where the company does not have the appropriate mechanisms and procedures of addressing the challenge. For instance, retail outlet managers may apply to relevant competent directorate to act as an arbitrator in the negotiation process. Article 107 B also gives the labor minister the authority to issue directives for requiring the employers to organize a collective bargaining forum to settle the disputes. The minister is also given powers by the constitution to issue a directive to the employer. Start collective bargaining process with their employees with the aim of finding a solution on stalemate due to workers grievances on promotion, working conditions and organizing closures and peaceful strikes. The management of the company has all the above avenues as per the provisions of the Oman labor laws to pursue in resolving the dispute. According to article 33 of the Omani labor laws, the workers of retail outlet are entitled to have a medical cover paid for them by their employers Omanis strike for a better pay and bonus). The labor law requires an employer with more than one hundred employees to hire a nurse who will be going round and offer first aid services to the employees an organization. The article also requires the employer to provide a